Read the following passage and mark the letter A, B, C or D to indicate the correct word or phrase that best fits each of the numbered blanks.

There are a lot of disadvantages of living in a big city, air pollution is among ___(1)___ most serious problems. Firstly, air pollution comes from the factories in the city. Big cities attract a lot of both inside and outside investments, ___(2)___ the number of factories is increasing quickly. This makes the air extremely ___(3)___ by smoke from factories. Secondly, that there are too many means also makes this problem worse. Exhaust from cars, motorbikes is one of the factors ___(4)___ make the air polluted. To conclude, air pollution, which expects to make more and more people get many serious ___(5)___ such as lung cancer, tuberculosis and so on, is a big drawback of city life.